Save mode retains (roughly) the current level of charge by topping it up using the engine when it has dropped. Charge will recharge the battery back up to~80% 'full'.
Very generally speaking, charging using petrol isn't very cost-effective, so the main use of Charge is if you're towing and know there's a long, steep uphill section ahead of you (like towing a caravan over the Alps), to reduce the risk of running out of battery power and dropping into tortoise/turtle mode.